From hidden to found in minutes

A cutting-edge faecal calprotectin test for precise gastrointestinal insights

What is GIQuest?

GIQuest is a new patient-side faecal calprotectin lateral flow test for assessing gastrointestinal inflammation in dogs and cats.

It supports the management of chronic inflammatory enteropathies including:

Inflammatory bowel disease (IBD)^1,2,3
Food responsive enteropathies (FRE)⁴
GI side-effects linked to NSAID use⁵

This new diagnostic tool can help guide the next steps for better patient management and outcomes.

Why use GIQuest?

The first of its kind, GIQuest provides fast, non-invasive and reliable results.

Clinically validated
Cost-effective
Results in just 15 minutes
Easy to perform
Aids clinical workflow

96% specificity and 94% sensitivity in dogs⁶

100% specificity and 92% sensitivity in cats⁶

When to use GIQuest

Measuring faecal calprotectin provides a non-invasive view of the gut.

Faecal calprotectin levels provide insight into the level of intestinal inflammation, aiding diagnosis of various disease conditions, as well as being used to monitor response to treatment.

GIQuest is a validated in-house test developed specifically for canine and feline gastrointestinal health.

GIQuest is simple to perform and interpret.

As a point-of-care test, it allows the user to get results in just 15 minutes, aiding workflow and guiding next steps.

Any cause of intestinal inflammation will result in elevated faecal calprotectin concentrations, including:

NSAID induced inflammation ^5,6
Food-responsive enteropathy ^4,6
Chronic inflammatory enteropathy ^{1-3, 6}
Infectious causes ^13,16
Carcinomas ^6,17

Studies in veterinary medicine show that faecal calprotectin levels correlate with clinical severity and decrease in response to treatment. ¹

Join the reveal-ution

Register to learn more about GIQuest and get support from our team.

Available to purchase with NVS, Covetrus and MWI

Däbritz J, Musci J, Foell D. Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. World J Gastroenterol 2014; 20(2): 363-375 [PMID: 24574706 DOI: 10.3748/wjg.v20.i2.363]
Heilmann RM, Suchodolski JS, Steiner JM. Development and analytic validation of a radioimmunoassay for the quantification of canine calprotectin in serum and feces from dogs. Am J Vet Res. 2008 Jul;69(7):845-53. doi: 10.2460/ajvr.69.7.845. PMID: 18593232.
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE. Calprotectin: from biomarker to biological function. Gut. 2021 Oct;70(10):1978-1988. doi: 10.1136/gutjnl-2021-324855. Epub 2021 Jun 18. PMID: 34145045; PMCID: PMC8458070.
Jones, S.M. et al. (2020) The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs. J Vet Intern Med. 34(5):1886-1893. doi: 10.1111/jvim.15897. Epub 2020 Sep 7. PMID: 32893926; PMCID: PMC7517840.J Vet Intern Med 34(5) :1886-1893
Heilmann RM, Berghoff N, Mansell J, Grützner N, Parnell NK, Gurtner C, Suchodolski JS, Steiner JM. Association of fecal calprotectin concentrations with disease severity, response to treatment, and other biomarkers in dogs with chronic inflammatory enteropathies. J Vet Intern Med. 2018 Mar;32(2):679-692. doi: 10.1111/jvim.15065. Epub 2018 Feb 20. PMID: 29460444; PMCID: PMC5866976.7. Badri D, et al. Curr Dev Nutr. 2019;3(suppl.1):nzz033.P09-001-19.
Stríz I, Trebichavský I. Calprotectin - a pleiotropic molecule in acute and chronic inflammation. Physiol Res. 2004;53(3):245-53. PMID: 15209531.
Otoni CC, Heilmann RM, García-Sancho M, Sainz A, Ackermann MR, Suchodolski JS, Steiner JM, Jergens AE. Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease. J Vet Intern Med. 2018 May;32(3):999-1008. doi: 10.1111/jvim.15123. Epub 2018 Apr 6. PMID: 29624721; PMCID: PMC5980281.
Ross FA, Park JH, Mansouri D, Combet E, Horgan PG, McMillan DC, Roxburgh CSD. The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterol. 2022 Apr 9;22(1):176. doi: 10
Simsek, A., Kochan, A., Yesilmen Alp, S., Sayin Ipek, D. N., & Icen, H. (2022). Serum Calprotectin Levels in Dogs with Diarrhea. Acta Scientiae Veterinariae, 50. https://doi.org/10.22456/1679-9216.119992
Nestler J, Syrjä P, Kilpinen S, Moniz CA, Spillmann T, Hanifeh M, Heilmann RM. Duodenal and colonic mucosal S100A8/A9 (calprotectin) expression is increased and correlates with the severity of select histologic lesions in dogs with chronic inflammatory enteropathy. BMC Vet Res. 2024 Sep 6;20(1):393. doi: 10.1186/s12917-024-04256-9. PMID: 39238011; PMCID: PMC11378391.
Weemhoff, J.L. et al. (2021) Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD’18 adherent clinical trial in dogs in the United States. I Vet Intern Med 35(4):1884-1892
Cuddy, K. (2018) Cutaneous adverse food reactions in dogs. Veterinary Ireland Journal. 8(2):110-113
Veterinary Medicines Directorate. Veterinary Pharmacovigilance in the United Kingdom. Annual Review, 2014.
Carus Animal Health, 2025, Data on File
Mabry, K. et al. (2021) Prevalence of gastrointestinal lesions in dogs chronically treated with nonsteroidal anti-inflammatory drugs. J Vet Intern Med. 35(2):853-859. doi: 10.1111/jvim.16057. Epub 2021 Feb 3. PMID: 33534961; PMCID: PMC7995375.
Enderle, L.L. et al. (2022) Verification of the fCAL turbo immunoturbidimetric assay for measurement of the fecal calprotectin concentration in dogs and cats. J Vet Diagn Invest 34(5):813-824 doi:1177/10406387221114031. Epub 2022 Jul 25. PMID: 35879875; PMCID: PMC9446300.
Klingberg, E. et al. (2017) A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis. Arthritis Res Ther 19, 21 https://doi.org/10.1186/s13075-017-1223-2
Tibble, J. A. et al. (1999) High prevalence of NSAID enteropathy as shown by a simple faecal test Gut 45:362-366.